Does Spyder Print work with CMYK printers?
Spyder Print builds -only- RGB printer profiles; it doesn't build CMYK printer profiles.
This has nothing to do with the kind of inks that are in these printers. There are no printers with RGB -inks-. All printers have CMYK inks, with typically some light cyan, light magenta, and in some cases, light gray inks as well. Just to be perfectly clear: as far as building profiles is concerned, we're not talking about inks here, we're talking about the color space/type of profiles that are used to adjust colors on the way to the printers during the printing process.
For all inkjet printers on the market today, that's not a problem, because by default, they all work as part of RGB-profiled workflows. Epson, Canon, and HP inkjet printers all work with RGB profiles.
CMYK profiling is more specialized, and is typically used for certain laser printers and specialty software RIP software.