It is important to move the color target grid to be centered within each patch.
There are two ways to make adjustments to the color target grid: Move your cursor into the center area of the target image. Left click and you can move the entire target grid. Each side of the target grid can be adjusted by moving your cursor just inside the blue half circle. When your cursor becomes two opposing arrows, you will be able to left click and move that side of the target grid.
Use both methods as needed until the patch grid lines up as close to the center of each patch as possible.