We found the problem that SpyderX, Spyder5 and Spyder4 may not create (save / overwrite) and/or activate the ICC profile correctly in Windows 10 May 2019 Update (Windows 10, Build 1903). Due to this problem, the correct color might not be displayed.
Microsoft has confirmed that there can be issues with color profiles with the 1903 update.
Please do this to resolve:
Update your Windows 10 using the Windows Update functionality to the Windows 10 build 1909 or higher.